Diseases of the Immune System (Microbiology)

Recall cards on diseases of the immune system. Hypersensitivities: the four types (I IgE and mast cells, II IgG/IgM against cell-surface antigens, III immune complexes, IV T-cell mediated), mast cell mediators, anaphylaxis, the ABO and Rh blood group systems, hemolytic transfusion reactions and hemolytic disease of the newborn, serum sickness, delayed-type hypersensitivity, hypersensitivity pneumonitis, skin testing, desensitization, and the hygiene hypothesis. Autoimmune disorders: loss of tolerance, antigenic mimicry, and specific diseases (celiac disease, Graves disease, Hashimoto thyroiditis, type 1 diabetes, Addison disease, multiple sclerosis, myasthenia gravis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus). Organ transplantation and rejection: autografts, isografts, allografts, and xenografts, human leukocyte antigens and HLA matching, the mechanism of rejection, immunosuppression, and graft-versus-host disease. Immunodeficiency: primary versus secondary, chronic granulomatous disease, X-linked agammaglobulinemia, selective IgA deficiency, and severe combined immunodeficiency. And cancer immunobiology: tumor antigens, the anti-tumor immune response, immune evasion, and preventive and therapeutic cancer vaccines and immunotherapies.